This dataset contains summary data visualizations and clinical data from a broad sampling of over 200 acute myeloid leukemias from 200 patients. The data was gathered as part of the PanCancer Atlas initiative, which aims to answer big, overarching questions about cancer by examining the full set of tumors characterized in the robust TCGA dataset. The clinical data includes mutation count, information...

TCGA Acute Myeloid Leukemia. Source data from GDAC Firehose. Previously known as TCGA Provisional. This dataset contains summary data visualizations and clinical data from a broad sampling of 200 carcinomas from 200 patients. The data was gathered as part of the Broad Institute of MIT and Harvard Firehose initiative, a cancer analysis pipeline. The clinical data includes mutation count, information...

Summary from ProteomeXchange: "Protein arginine methyltransferase 5 (PRMT5) belongs to the class II arginine methyltransferases and catalyzes monomethylation and symmetrical dimethylation of arginines on proteins. It has recently emerged as a promising cancer drug target, and two PRMT5 inhibitors are currently in clinical trials for a range malignancies. Despite the recognized therapeutic potential,...

Summary from the GEO: "Protein arginine methyltransferase 5 (PRMT5) belongs to the class II arginine methyltransferases and catalyzes monomethylation and symmetrical dimethylation of arginines on proteins. It has recently emerged as a promising cancer drug target, and three PRMT5 inhibitors are currently in clinical trials for a range of malignancies. In this study, we aimed to further elucidate the...

Summary from the GEO: "RNA-sequencing on human leukemia cell lines MOLM13 (AML, MLL-AF9+) and K562 (CML-BC, BCR-ABL+) after Ro 08-2750 treatment (20 uM, 4hours). Cells were cultured at 0.5M/mL and treated with the small-molecule Ro 08-2750 for 4hours at 20 uM." The dataset is associated with the MUSASHI (MSI) family of RNA binding proteins (MSI1 and MSI2). According to the associated article, the...

This dataset contains the summary data visualizations and clinical data of 21 samples from 11 patients of targeted and WES sequencing of germ cell tumor and shared leukemia samples. Clinical data includes: Cancer Type, Number of Samples per Patient, Mutation Count, Fraction Genome Altered, Specimen Preservation Type, Platform and Somatic Status. The plaintext components of the dataset can be downloaded...

This dataset contains the summary data visualizations and clinical data from 4,231 myeloid neoplasm samples from 4,231 patients. Clinical data includes: Cancer Type, Cancer Type Detailed, Mutation Count, Oncotree Code, Sequencing Type, Somatic Status, Study. The plaintext components of the dataset can be downloaded as a tar file. The clinical data can be downloaded as a tsv file.

Description from GEO: "Background: Acute myeloid leukemia (AML) is driven by somatic mutations and genomic rearrangements affecting >20 genes. Many of these are recent discoveries and how this molecular heterogeneity dictates AML pathophysiology and clinical outcome remains unclear. Methods: We sequenced 111 leukemia genes for driver mutations in 1540 AML patients with cytogenetic and clinical data....

Study Description from dbGaP: "To further explore some more aggressive subtypes in pediatric cancer already under study in OCG, CGCI is partnering with TARGET initiative to support extensive sequencing analysis of three hard to treat childhood cancers: refractory to treatment cases of acute myeloid leukemia and two rare kidney tumors; clear cell sarcoma of the kidney and rhabdoid tumor (RT). Rhabdoid...

Summary from the GEO: "Haematopoietic stem cells (HSCs) tightly regulate their quiescence, proliferation, and differentiation to generate blood cells during the entire lifetime. The mechanisms by which these critical activities are balanced are still unclear. Here, we report that Macrophage-Erythroblast Attacher (MAEA, also known as EMP), a receptor thus far only identified in erythroblastic island1,...